A new study shows that exposure to two specific 'forever chemicals' may accelerate biological aging, especially in middle-aged men. Researchers revealed a link between faster epigenetic aging, and two of these alternatives, PFNA and PFOSA, a precursor of PFOA.

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If I still want to apply changes immediately, I can use the rpm-ostree apply-live command which will apply changes without restarting the system (but some modifications may require a reboot to be fully effective).

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